Interleukin-23 may contribute to the pathogenesis of lumbar disc herniation through the IL-23/IL-17 pathway
نویسندگان
چکیده
منابع مشابه
Interleukin-23 may contribute to the pathogenesis of lumbar disc herniation through the IL-23/IL-17 pathway
BACKGROUND Studies have indicated that interleukin 23 (IL-23) plays an important role in many inflammatory- and autoimmune-related diseases. However, there is little knowledge about IL-23 in lumbar disc herniation (LDH). Thus, in this study, we aimed to find out whether IL-23 is expressed in intervertebral discs (IVDs) and what roles it may play. METHODS Human IVD tissues were collected from ...
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inflammation is an important reaction underlying lumbar disc herniation (ldh). th17 cells play a critical role in immune activation. interleukin (il)-21 controls the functional activity of effector t-helper cells and the differentiation of th17 cells, and promotes b-cell differentiation. it plays important roles in chronic inflammation and autoimmune diseases. however, little is known about rel...
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متن کاملInterleukin-21 Is Associated with the Pathogenesis of Lumbar Disc Herniation.
Inflammation is an important reaction underlying lumbar disc herniation (LDH). Th17 cells play a critical role in immune activation. Interleukin (IL)-21 controls the functional activity of effector T-helper cells and the differentiation of Th17 cells, and promotes B-cell differentiation. It plays important roles in chronic inflammation and autoimmune diseases. However, little is known about rel...
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ژورنال
عنوان ژورنال: Journal of Orthopaedic Surgery and Research
سال: 2016
ISSN: 1749-799X
DOI: 10.1186/s13018-016-0343-8